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Landmark articles in “Acute Pulmonary Embolism”


Risk stratification

  1. Konstantinides S. Acute Pulmonary Embolism. N Engl J Med 2008; 359:2804-2813.


Diagnosis & Management (guidelines)

  1. Torbicki A et al. Guidelines on the diagnosis and management of acute pulmonary embo- lism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embo- lism of the European Society of Cardiol- ogy (ESC). Eur Heart J 2008;29:2276-315.

  2. Gordon H et al. Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. CHEST 2012; 141(2)(Suppl):7S–47S.

  3. Konstantinides SV et al. 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism. European Heart Journal 2014; 35, 3033–3080.

  4. Jaff et al . Management of Massive and Submassive Pulmonary Embolism, Iliofemoral Deep Vein Thrombosis, and Chronic Thromboembolic Pulmonary Hypertension: A Scientific Statement From the American Heart Association.Circulation 2011;123:1788-1830.



  1. Dalla-Volta S et al. PAIMS 2: alteplase combined with heparin versus heparin in the treatment of acute pulmonary embolism. Plasminogen activa- tor Italian multicenter study 2. J Am Coll Cardiol 1992;20(3):520 – 526. 

  2. Meyer G. Fibrinolysis for Patients with Intermediate Risk Pulmonary Embolism. N Engl J Med 2014;370:1402-11.


Surgical & catheter Thrombectomy

  1. Kilic A et al. Nationwide outcomes of surgical embolec- tomy for acute pulmonary embolism. J Thorac Cardiovasc Surg 2013;145(2): 373 – 377. 

  2. Aymard T et al. Massive pulmonary embolism: surgical embolectomy versus thrombolytic therapy: should surgical indications be revisited? Eur J Cardiothorac Surg 2013;43(1): 90–94.

  3. Kuo WT et al. Catheter- directed therapy for the treatment of massive pulmonary embolism: systematic review and meta-analysis of modern techniques. J Vasc Interv Radiol 2009;20(11): 1431 – 1440 .

  4. Engelberger RP et al.Ultrasound-assistedthrombolysisforacutepulmonary embolism: a systematic review. Eur Heart J 2014;35(12):758 – 764.



  1. Malekan R et al. Peripheral extracorporeal membrane oxygenation: comprehensive therapy for high- risk massive pulmonary embolism. Ann Thorac Surg 2012;94(1):104 – 108. 



  1. Agnelli G et al. Acute Pulmonary Embolism. N Engl J Med 2010; 363:266-274.




Compiled by-

Dr Sananta K Dash

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